Microchip reservoir devices using wireless transmission of power and data

ABSTRACT

Devices, systems, and methods are provided for wirelessly powering and/or communicating with microchip devices used for the controlled exposure and release of reservoir contents, such as drugs, reagents, and sensors. In one embodiment, the system includes (1) a microchip device comprising a substrate having a plurality of reservoirs containing reservoir contents for release or exposure; and (2) a rechargeable or on-demand power source comprising a local component which can wirelessly receive power from a remote transmitter wherein the received power can be used, directly or following transduction, to activate said release or exposure of the reservoir contents. In another embodiment, the system comprises (1) a microchip device comprising a substrate a plurality of reservoirs containing reservoir contents for release or exposure; and (2) a telemetry system for the wireless transfer of data between the microchip device and a remote controller.

CROSS-REFERENCE TO RELATED APPLICATIONS

Priority is claimed under 35 U.S.C. § 119 to U.S. provisionalapplication Ser. No. 60/239,222, filed Oct. 10, 2000.

BACKGROUND OF THE INVENTION

This invention relates to miniaturized devices for the controlledexposure or release of molecules such as drugs and/or secondary devicessuch as sensors.

Microchip devices for chemical and drug delivery and for controlledexposure of reservoir contents have been described in detail in U.S.Pat. No. 5,797,898; U.S. Pat. No. 6,123,861; PCT WO 01/64344; and PCT WO01/35928. One group of embodiments of these microchip devices providesactive release or exposure of the contents of a reservoir in thesubstrate of the device. “Active” is used to refer to those embodimentsin which release or exposure is initiated at a particular time by theapplication of a stimulus to the device or a portion of the device.

An important application for these active microchip devices is to serveas an implantable device for the delivery of drugs in the body of humansand animals, for the treatment or diagnosis of disease. Due to its smallsize, the microchip device may be implanted in the body in a variety oflocations, including, but not limited to, under the skin and in theperitoneal cavity. The device may also be ingested for drug delivery orcontent exposure throughout the gastrointestinal tract. Flexibility ofimplant location and site variation are particularly important, forexample when local, rather than systemic, administration is desired.Currently available implantable drug delivery devices such as pumps maybe too large for use in many of locations in the body.

U.S. Pat. No. 5,797,898 to Santini, et al., describes powering theactive microchip devices using pre-charged power sources (e.g.,pre-charged micro-batteries), which can be integrated with the microchipand its associated electronics. Such a pre-charged micro-battery can bea thin film battery fabricated on the microchip substrate itself, or itcan exist as a separate component that is connected to the microchipsubstrate through interconnects and packaging. Such power sourcesgenerally must store all the power required during the operatinglifetime of the microchip device. If it cannot store all of the requiredpower during the intended useful life of the microchip device, then thedepleted battery must be replaced with a new battery. However, suchreplacement typically is impractical or undesirable for an implanteddevice. It would therefore be advantageous to avoid the need for batteryreplacement. Furthermore, conventional means of powering an implantabledevice may be unsuitable for a variety of implanted devices,particularly for all possible implant locations.

U.S. Pat. No. 5,797,898 also describes incorporating a pre-programmedmicroprocessor into the active microchip device to control whichreservoirs are activated and when they are activated. The microprocessoris disclosed as being fabricated onto the back of the microchipsubstrate. It would be advantageous to be able to alter the programmingafter implantation in order to make the microchip device more flexibleand adaptable to various applications, particularly implantapplications.

It is therefore an object of the present invention to provide devicesand methods for reducing or eliminating the need for pre-charged powersources for active release microchip devices.

It is another object of the present invention to provide devices andmethods for avoiding explantation of implanted microchip devices for thepurpose of replacing or recharging the device's power source or for thepurpose of reprogramming the device's microprocessor.

It is a further object of the present invention to provide additionalmeans for powering and communicating with microchip drug delivery andsensing devices.

These and other objects, features, and advantages of the presentinvention will become apparent upon review of the following detaileddescription of the invention taken in conjunction with the drawings andthe appended claims.

SUMMARY OF THE INVENTION

Devices, systems, and methods are provided for wirelessly poweringand/or communicating with microchip devices used for the controlledexposure and release of reservoir contents, such as drugs, reagents, andsensors.

In a preferred embodiment, the system for the controlled release orexposure of reservoir contents comprises (1) a microchip devicecomprising a substrate having a plurality of reservoirs containingreservoir contents for release or exposure; and (2) a rechargeable oron-demand power source comprising a local component which can wirelesslyreceive power from a remote transmitter; wherein the received power canbe used, directly or following transduction, to activate said release orexposure of the reservoir contents. These systems advantageously do notrequire a power storage unit to be physically connected to or integratedinto the microchip device. For example, the local component can beadapted to receive power from an electromagnetic energy source, such asradio frequency signals or a laser, and/or from a sonic energy source,such as an ultrasound generator. The system optionally can include arechargeable power storage unit, such as a capacitor or rechargeablebattery. However, it need not store all of the power required for theoperating life of the microchip, since additional power can wirelesslybe transmitted and received when needed (i.e. on-demand). Therechargeable power storage unit can include, for example, a coil for thereceipt of electromagnetic energy, a photocell, a hydrophone, or acombination thereof.

The system may further include actuation electronics, local controllers,and a telemetry system. Actuation electronics, such asmultiplexers/demultiplexers, selectively control and direct the power toselectively open the reservoirs. The local controller can control theactuation electronics, and may include microprocessors, read onlymemory, random access memory, clocks, analog input/output devices,digital input/output devices, programmable logic circuits, andcombinations thereof. A telemetry system wirelessly transfers data(e.g., a signal) between the microchip device and a remote controller.

In another preferred embodiment, the system for the controlled releaseor exposure of reservoir contents comprises (1) a microchip devicecomprising a substrate a plurality of reservoirs containing reservoircontents for release or exposure; and (2) a telemetry system for thewireless transfer of data between the microchip device and a remotecontroller. The system can further comprise actuation electronics toselectively open the reservoirs, as well as a local controller (whichtypically would be in wireless communication with the remote controllerof the telemetry system) for controlling the actuation electronics.

The data transfer can be accomplished using a first coil in themicrochip device to inductively couple electromagnetic energy to acorresponding coil in the remote controller. Alternatively, the transfermay utilize various kinds of transmitters and receivers. For example,the microchip device can comprise a receiver which includes photocells,photodiodes, phototransistors, and/or ultrasonic receivers, where theremote controller comprises a light-emitting diode (LED), a laser,and/or an ultrasonic transmitter. For example, LED's can be fabricatedon or in the microchip device, wherein the LED can be used to transmitenergy or data to other components of the system, such asexternal/internal transmitters or remote controllers using light ofvarying wavelengths.

It should be noted that the wireless transmission of power and thewireless transmission of data can be transmitted to the microchip devicein the same signal and then separated appropriately in the microchipdevice.

The microchip device systems can be used in a variety of applications. Apreferred application is the controlled delivery of a drug, chemicalreagent, or biosensor to sites within the body of a human or animal. Inone example, the microchip device is adapted for implantation onto or inthe eye of a human or animal, and the remote controller and/or powersource comprises an ophthalmic laser. In another example, the microchipdevice is adapted for oral administration, and the remote controllercomprises a radio frequency transmitter.

The system also has a variety uses that are not limited to implantation.For example, the reservoir contents may include a sensor for detecting achemical or biological molecule at the site in which the microchip isplaced, and the telemetry system transmits a status of the sensordetection to the remote controller. Such a site could be in vivo or invitro. The chemical or biological molecule could, for example, beassociated with a chemical or biological weapon, and the system used inan early warning/detection system.

In a preferred variation of the embodiments described above, eachreservoir can have a reservoir cap positioned on the reservoir over thereservoir contents, wherein release or exposure of the reservoircontents is controlled by diffusion through or disintegration of thereservoir cap. The reservoir cap can be an anode, such that uponapplication of an electric potential between a cathode and the anode thereservoir cap is oxidized to facilitate its disintegration, therebyexposing the reservoir contents to a surrounding fluid.

The reservoir content preferably is a drug, a biosensor, or acombination thereof.

BRIEF DESCRIPTION OF THE FIGURES

FIG. 1 is a schematic showing the primary components of a system for thewireless transmission of power or data to or from a microchip device forthe release or exposure of reservoir contents.

FIG. 2( a) illustrates one embodiment of a configuration of a microchipsystem for drug release into the eye that is equipped for power and datatransmittal by laser, and FIG. 2( b) illustrates a process of using anophthalmic laser to transmit power and data to a drug delivery implantin the eye.

FIG. 3 is a diagram illustrating how a microchip device can be activatedat a specific location in the gastrointestinal tract based on thelocation of a drug delivery microchip relative to an RF transmitter.

DETAILED DESCRIPTION OF THE INVENTION

Devices, systems, and methods have been developed for wirelesslypowering and/or communicating with microchip devices used for thecontrolled exposure and release of reservoir contents, such as drugs,reagents, and sensors.

The Microchip Device Systems

The systems include a microchip device, along with means for wirelesslydelivering power (i.e. energy) to the microchip device, means forwirelessly transferring data between the microchip device and a remotecontroller, or both means.

The Microchip Device

The microchip device is described in U.S. Pat. Nos. 5,797,898 and6,123,861, both to Santini, et al., and PCT WO 01/64344, WO 01/41736, WO01/35928, and WO 01/12157, which are hereby incorporated by reference intheir entirety. Each microchip device includes a substrate having aplurality of reservoirs containing reservoir contents for release orexposure. In a preferred embodiment, each reservoir has a reservoir cappositioned on the reservoir over the reservoir contents, wherein releaseor exposure of the reservoir contents is controlled by diffusion throughor disintegration of the reservoir cap. The reservoir cap can be ananode, such that upon application of an electric potential between acathode and the anode the reservoir cap is oxidized to facilitate itsdisintegration, thereby exposing the reservoir contents to a surroundingfluid.

In another embodiment, the reservoir cap includes an electrically-orthermally-responsive polymer whose integrity or porosity can bemodulated (i.e. increased or decreased) upon application of electricalenergy to the reservoir cap (e.g., for the electrically responsivepolymer) or to a nearby resistor (e.g., for the thermally responsivepolymer). Similarly, the reservoir cap can include or be formed of apolymer having a porosity that can be modulated by application ofelectromagnetic energy, acoustic energy, or a particular chemicalspecies (e.g., for chemical actuation) provided by the microchip deviceor other source.

The microchip reservoir contents can be essentially any chemical orminiature device. In a preferred embodiment, the chemical is atherapeutic, prophylactic, or diagnostic agent. (The term “drug” is usedherein to refer any of these agents.) Preferred drug deliveryapplications include potent compounds, including both small and large(i.e. macro) molecules, such as hormones, steroids, chemotherapymedications, vaccines, gene delivery vectors, and some strong analgesicagents. An example of a diagnostic agent is an imaging agent such as acontrast agent. Other molecules that can be released include fragrancesand flavoring agents.

The reservoir contents also can be catalyst (e.g., zeolites, enzymes),one or more reagents, or a combination thereof. In another embodiment,the reservoir content includes a secondary device such as a sensor andsensing component, e.g., a biosensor. Examples of sensing componentsinclude components utilized in measuring or analyzing the presence,absence, or change in a chemical or ionic species, electromagnetic orthermal energy (e.g., light), or one or more physical properties (e.g.,pH, pressure) at a site. The contents may either be released from orremain immobilized in the reservoir, depending on the particularapplication. Individual reservoirs may contain multiple types ofchemicals, multiple types of devices, or combinations of devices andchemicals.

The microchip devices can be made and assembled using microfabricationmethods known in the art, particularly those methods described andreferenced in U.S. Pat. Nos. 5,797,898 and 6,123,861, both to Santini,et al., and in PCT WO 01/64344, WO 01/41736, WO 01/35928, and WO01/12157.

Wireless Powering Means/On-Demand Power Sources

Means of supplying power to active-release microchip devices include theuse of a precharged power source (which contain all of the powerrequired for operation over the life of the microchip device), a sourcethat can be periodically recharged, and an on-demand power source. Thelatter two power sources are preferred.

The microchip device typically includes a transducer for receivingenergy wirelessly transmitted to the device, circuitry for directing orconverting the received power into a form that can be used or stored,and if stored, a storage device, such as a rechargeable battery orcapacitor. Therefore in preferred embodiments, the system for thecontrolled release or exposure of reservoir contents includes amicrochip device and a rechargeable or on-demand power source. Theon-demand power source advantageously does not require that a powerstorage unit to be physically connected to or integrated into themicrochip device. The rechargeable power source (i.e. the rechargeablepower storage unit) can store power, but advantageously need not storeall of the power required for the operating life of the microchip. Therechargeable power source and on-demand power sources can both beincluded in a single microchip device, as it is common for a systemhaving an on-demand power source to include a power storage unit, suchas a capacitor or battery.

The systems described herein preferably are provided with a means formonitoring the state of any power storage unit. As power is used ordepleted from the storage device, additional power can wirelessly betransmitted to and received by the rechargeable power storage unit whenneeded. Rechargeable power sources provide a means of extending theoperating life of the microchip device beyond that possible withpre-charged storage cells or non-rechargeable systems.

Systems and techniques for on-demand power by wireless transmission,which can be adapted for use with the microchip devices describedherein, are disclosed, for example, in U.S. Pat. No. 6,047,214 toMueller, et al.; U.S. Pat. No. 5,841,122 to Kirchhoff; U.S. Pat. No.5,807,397 to Barreras; and U.S. Pat. No. 5,324,316. The systemstypically involve a receiver and a transmitter of one or more forms ofenergy. The rechargeable or on-demand power source preferably includes alocal component which can wirelessly receive power from a remotetransmitter. As used herein, the term “local” refers to being local tothe microchip device (rather than remote), and includes, but is notlimited to, having the local component attached to the microchip device,such as by fabrication onto the substrate.

The local component can be adapted to receive power by a variety ofmeans. For example, the local component can be adapted to receive powerfrom an electromagnetic (EM) energy source, or an acoustic (i.e. sonic)energy or other mechanical energy source. Electromagnetic energy refersto the full spectral range from x-ray to infrared. Representativeexamples of useful EM energy forms include radio frequency signals andlaser light. A representative example of a useful form of acousticenergy is ultrasound. In various embodiments, the rechargeable powerstorage unit can include, for example, a coil for the receipt ofelectromagnetic energy, or a means for transducing other types ofenergy, such as a photocell, a hydrophone, or a combination thereof.Additional components may include a means of power conversion such as arectifier, a power storage unit such as a battery or capacitor, and anelectric potential/current controller (i.e. potentiostat/galvanostat).

The microchip device also can include a component to convert mechanicalor chemical energy from the body of the human or animal into power (i.e.energy) which can be used to activate release or exposure of thereservoir contents. For example, components comprising accelerometersand gyroscopes, can be used to convert motion of a body into electricalenergy. Similarly, an implanted transducer can convert heartbeats intouseful energy, as currently is done with some pacemaker designs. See,e.g., U.S. Pat. No. 5,713,954. In another embodiment power isgenerated/converted from a chemical energy source. For example, themicrochip can comprises a biofuel cell which generates the power bychemically reacting a molecule present in the body. Examples of thesefuel cells are described for example in Palmore & Whitesides, “Microbialand Enzymatic Biofuel Cells,” Enzymatic Conversion of Biomass for FuelProduction, ACS Symposium Series 566:271-90 (1994); Kano & Ikeda,“Fundamentals and practices of mediated bioelectrocatalysis,” AnalyticalSci., 16(10):1013-21 (2000); and Wilkenson, Autonomous Robots, 9(2):99-111 (2000). In a typical embodiment, the implanted device would havean immobilized enzyme which would react with a biological molecule tocause electron transfer, thereby causing an electric current to flow.Possible useful biological molecules include triphosphates, such as ATP,and carbohydrates, such as sugars, like glucose.

Many of these components (except for the external energy transmissionsource) may be fabricated on the microchip (“on-chip” components) usingknown MEMS fabrication techniques, which are described, for example, inMadou, Fundamental of Microfabrication (CRC Press, 1997) or using knownmicroelectronics processing techniques, which are described, forexample, in Wolf & Tauber, Silicon Processing for the VLSI Era (LatticePress, 1986). Each of these components (except the external energytransmission source) also may exist as discrete, “off the shelf”microelectronic components that can be connected to the microchipdevices through the use of hybrid electronic packaging or multi-chipmodules (MCMs). An active-release microchip device with the capabilityof receiving power through wireless means also can be composed of acombination of “on-chip” components and “off the shelf” components.

The particular power needs of the microchip device will depend on theapplication for and the specific design of the microchip device.Examples of design factors include the size requirements and anticipatedoperating life of the device. The particular devices and techniques fortransmitting power will likely depend on the selected sites for themicrochip device and remote transmitter. For example, for an implantedmicrochip, the body tissue will affect the transmission of power from anexternally located transmitter. For example, inductively coupledelectromagnetic energy typically penetrates body tissues to a limitedextent; however, sonic energy, e.g., ultrasound, is readily transmittedthrough tissue and bodily fluids. As another example, although light(e.g., visible light) is generally not transmitted through tissue, itmay be easily transmitted through the aqueous and vitroeous humor of theeye. However, other electromagnetic radiation, for example x-rays, mayreadily be transmitted through tissue, depending primarily upon thewavelength of the radiation.

In one form, the system provides remote recharging of a battery forpowering a microchip device.

In one embodiment having an in vivo rechargeable power storage unit, thepower storage unit is separate from the other in vivo electroniccomponents and communicates with them by wire or by in vivo telemetry.See for example, the implantable heart apparatus and energy transfersystems described in PCT WO 01/37926 and WO 01/28629.

The system may further include a telemetry system to wirelesslytransfers data (e.g., a signal) between the microchip device and aremote controller or between components of the microchip device.

Wireless Communication Means/Telemetry System

Means for sending and receiving data using wireless technology aresimilar to those described for the wireless transmission of power. In apreferred embodiment, the system for the controlled release or exposureof reservoir contents includes a microchip device and a telemetry systemfor the wireless transfer of data between the microchip device and aremote controller. Generally, the telemetry system includes atransmitter and a receiver. A transmitter can be included in the remotecontroller, the microchip device, or both when data is transferred inboth directions (to/from the microchip device), when the receiver isincluded in the microchip device, the remote controller, or both,respectively. As used herein, the “remote controller” therefore caninclude a transmitter, a receiver, or both.

Generally, the telemetry (i.e. the transmitting and receiving) isaccomplished using a first coil to inductively couple electromagneticenergy to a matching/corresponding second coil. The means of doing thisare well established, with various modulation schemes such as amplitudeor frequency modulation used to transmit the data on a carrierfrequency. The choice of the carrier frequency and modulation schemewill depend on the location of the device and the bandwidth required,among other factors. Other data telemetry means also may be used.Examples include optical communication, where the receiver is in theform of a photocell, photodiode, and/or phototransistor, and where thetransmitter a light-emitting diode (LED) or laser. For example, an LEDcould be fabricated into the silicon microchip substrate, either insideor outside of the reservoirs, by using or adapting techniques such asthose described in Barillo, et al., “A porous silicon LED based on astandard BCD technology”, Optical Materials 17(1-2):91-94 (2001).Optical telemetry techniques are further described, for example, in U.S.Pat. No. 6,243,608. For telemetry through soft tissue of the body,acoustic (i.e. sonic) energy, such as ultrasound energy, may be used asa means of communication. See, e.g., U.S. Pat. No. 6,140,740. Oneskilled in the art can adapt these known telemetry means for use with amicrochip device to optimize power and data exchange. For example, onecan account for impedance matching with tissue and receptive field andother factors for optimizing ultrasound transmission.

In various embodiments, the microchip device is provided with a receiverthat accepts commands and data from the remote controller, and may beused to actuate a reservoir, to request status information about thestate of the system or an event log, or to reprogram the controlleroperating system (e.g., the internal firmware). In an embodiment inwhich the microchip device is implanted in a human or animal, the remotecontroller can include a means of display and/or actuation that can beused by the physician or patient to operate and monitor the microchipdevice. For example, the microchip may wirelessly transmit to a remotecontroller, comprising a receiver, information about the batterycondition and the location and number of reservoirs used and remaining.Additional support circuitry may be used to interface to biosensors orother types of devices such as pacemakers or defibrillators.

Other Components and Features of the Systems

It should be noted that the wireless transmission of power and thewireless transmission of data can be transmitted to the microchip devicein the same signal and then separated appropriately in the microchipdevice.

The systems described herein may further include actuation electronicsand local controllers. Actuation electronics selectively control anddirect the power to the desired reservoirs. The actuation electronicscontains circuitry to condition the power in a form that is needed foropening the reservoirs. For example, this circuitry may include signalgenerators/oscillators, voltage or current sources, amplifiers, and/orswitches. For metal film reservoir caps, the actuation electronicspreferably includes a potentiostat. Representative types of actuationelectronics include potentiostat/voltage sources, galvanostat/currentsources, multiplexers, and demultiplexers. In a preferred embodiment,the actuation electronics preferably includes a demultiplexer to routethe power to the desired reservoirs. The demultiplexer may be integratedon the microchip or may be a separate chip or electrical component.

The local controller can control the actuation electronics and typicallyis responsible for operation of the device. The complexity of thecontroller will depend on the particular application of the microchip.The controller generally is either a microprocessor-based system or adedicated logic circuit with a finite number of operational states. Inthe case of a microprocessor system, there preferably is amicroprocessor, memory (read-only and random-access), clock, analoginput/output devices, and digital input/output devices. The memorygenerally will contain a set of instructions to be executed by themicroprocessor. These instructions can include routines to actuate thereservoirs, to receive commands or data from the remote controller, totransmit information to the remote controller, and to measure andinterpret signals from devices such as sensors. A controller based on adedicated logic circuit may be controlled by the receipt of commands ordata in the form of an encoded (voltage) signal. See, e.g., U.S. Pat.No. 5,324,316, which describes using a dedicated logic circuit as acontroller of an implantable microstimulator. The components of thecontroller system may be integrated as part of the microchip on the samesubstrate, or may be separate local components.

Use of the Microchip Devices and Systems

The microchip device systems can be used in a wide variety ofapplications. The applications can be ex vivo or in vitro, but morepreferably are for in vivo applications, particularly following non- orminimally-invasive implantation.

Preferred applications for using the devices and systems include thecontrolled delivery of a drug (i.e. a therapeutic, prophylactic, ordiagnostic agent) to sites within the body of a human or animal,biosensing, or a combination thereof. The microchip systems areespecially useful for drug therapies in which it is desired to controlthe exact amount, rate, and/or time of delivery of the drug. Preferreddrug delivery applications include the delivery of potent compounds,including both small and large molecules, such as hormones, steroids,chemotherapy medications, vaccines, gene delivery vectors, and somestrong analgesic agents.

The microchips can be implanted via surgical procedures or injection, orswallowed, and can deliver many different drugs, at varying rates andvarying times. In one example, the microchip device is adapted forimplantation onto or in the eye of a human or animal, and the remotecontroller comprises an ophthalmic laser. In another example, themicrochip device is adapted for oral administration, and the remotecontroller comprises a radio frequency transmitter.

In another preferred embodiment, the microchip device includes one ormore biosensors (which may be sealed in reservoirs until needed for use)that are capable of detecting and/or measuring signals within the bodyof a patient. As used herein, the term “biosensor” includes, but is notlimited to, sensing devices that transduce the chemical potential of ananalyte of interest into an electrical signal, as well as electrodesthat measure electrical signals directly or indirectly (e.g., byconverting a mechanical or thermal energy into an electrical signal).For example, the biosensor may measure intrinsic electrical signals(EKG, EEG, or other neural signals), pressure, temperature, pH, or loadson tissue structures at various in vivo locations. The electrical signalfrom the biosensor can then be measured, for example by amicroprocessor/controller, which then can transmit the information to aremote controller, another local controller, or both. For example, thesystem can be used to relay or record information on the patient's vitalsigns or the implant environment, such as blood gases, drugconcentration, or temperature.

The system also has a variety uses that are not limited to implantation.For example, the reservoir contents may include a sensor for detecting achemical or biological molecule at the site in which the microchip isplaced, and the telemetry system transmits a status of the sensordetection to the remote controller. Such a site could be in vivo or invitro. The chemical or biological molecule could, for example, beassociated with a chemical or biological weapon, and the system used inan early warning/detection system.

Active microchip devices may be controlled by local microprocessors orremote control. Biosensor information may provide input to thecontroller to determine the time and type of activation automatically,with human intervention, or a combination thereof. The microchip deviceshave numerous in vivo, in vitro, and commercial diagnostic applications.The microchips are capable of delivering precisely metered quantities ofmolecules and thus are useful for in vitro applications, such asanalytical chemistry and medical diagnostics, as well as biologicalapplications such as the delivery of factors to cell cultures.

The present invention can best be understood with reference to thefollowing non-limiting examples.

EXAMPLE 1

Chemical Releasing Microchip with Electrochemical Actuation and RF PowerTransmission

An electrochemically actuated microchip device having reservoirs coveredby thin film gold reservoir caps can be fabricated using the processesdescribed in U.S. Pat. No. 6,123,861. The reservoirs contain drug orother molecules for release. Application of an electric potential ofapproximately 1.0 volt (with respect to a saturated calomel referenceelectrode) in the presence of chloride ions would cause the reservoircaps to oxide and disintegrate, releasing the material stored in thereservoir. An on-demand power and control system would include an RFgenerating and a transmission source in an external controller unit. Themicrochip device would include a receiver coil (i.e. an inductor), anoptional power converter (rectifier, regulator), a power storage unit(e.g., a capacitor, micro-battery), optional potentiostat or galvanostatcircuitry (if electric potential or current modulation is required), ademultiplexer, a timer, and a microprocessor.

When release from a particular reservoir is desired, an RF signal is(wirelessly) transmitted to the reservoir-containing microchip device.The RF signal would induce an AC electric current in the receiver coil.This RF generated AC current can be rectified to DC current and directedto a unit for power storage, or if the electric current/corrosionbehavior of the reservoir cap is well characterized, then the currentcan be sent directly to the anode reservoir cap covering the particularreservoir from which release is desired. In some cases, the receivedpower is directed through a galvanostat or potentiostat to modulate thecurrent or to produce a specific electric potential (relative to areference electrode) at the reservoir cap. The electric current orpotential is directed to the correct reservoir by amicroprocessor-controlled demultiplexer. The microprocessor can becoupled with memory and a timer to enable timed dose regimens to bestored on-chip. The microprocessor then can direct power from the powerstorage unit or directly from the AC to DC converter to the correctreservoir in a particular release pattern programmed into the memory.

The release pattern also could be controlled in a wireless manner viacommands sent from a remote controller over a telemetry system.Alternatively, the delivery of the drug or other molecule could becontrolled by feedback from a biosensor located on or near themicrochip, and interfaced to the controller.

This example may be better understood with reference to FIG. 1, which isa schematic that illustrates the primary components and the flow ofpower and data in a typical wireless microchip system.

EXAMPLE 2

Microchip for the Selective Exposure of Reservoir Contents with ThermalActivation and RF Power Transmission

A microchip device similar to that described in Example 1 can be madewith reservoirs containing catalysts for reactions and/or sensors forchemical and biological agent detection, wherein power transmitted bywireless methods can be used to open the reservoirs to selectivelyexpose the contents. In this embodiment, electromagnetic energy istransmitted to a receiver coil located on or connected to the microchipdevice. The induced AC current can be rectified to DC current to chargea storage battery or capacitor, or sent directly to resistors locatedon, near, or inside the reservoirs that are to be opened. Currentpassing through the resistor will cause a temperature rise in theresistor and surrounding area. The rise in temperature can cause thereservoir cap material to disintegrate, melt, or phase change andselectively expose the sensor or catalyst. Alternatively, a temperaturerise inside the reservoir can result in a rise in pressure inside thereservoir that may cause the reservoir cap to rupture, exposing thecontents of the reservoir to the surrounding environment. As in Example1, the direction of the power to the proper reservoir is accomplishedthrough the use of a demultiplexer controlled by a preprogrammedmicroprocessor, remote control, or biosensor.

EXAMPLE 3

Microchip for Release of Drug to the Eye Using Laser Actuation

Lasers are used routinely in eye surgeries and other eye procedures forthe treatment of conditions such as diabetic retinopathy, retinaldetachments, age-related macular degeneration. Some conditions, notablymacular degeneration, can be treated with periodic administration ofmedication delivered to the eye; however currently available means fordoing so, such as injections, are difficult. To overcome suchdifficulties, an implantable microchip device can be provided to deliverdoses of one or more types of medication to the eye on a periodic basisfor an extended period of time. As the power requirements forelectrochemically actuated silicon microchip devices with thin film goldreservoir caps are sufficiently small, the power can be wirelesslysupplied, for example, via an ophthalmic laser. The ophthalmic laseralso could be used to wirelessly communicate instructions to theimplanted microchip device. Both power and data can be transmitted, forexample, by modulating the signal that will carry the power; themodulation information to be communicated to the implanted microchipdevice.

Such an implantable wireless ocular delivery system would typicallyinclude (1) the drug-containing microchip with its local controller,external interfaces, power conversion electronics, and actuationelectronics; and (2) the ophthalmic laser. The external interface andpower conversion electronics typically would include a photocell toreceive the incident light energy, circuitry to generate the neededvoltage, storage means such as a capacitor or battery, and circuitry todecode information transmitted by modulating the laser input. Thecontroller typically would be a microprocessor with associated supportcircuitry such as a memory and a clock, although a dedicated integratedcircuit may work for some embodiments. Electronics required to actuateelectrochemical microchips typically would include means for controllingthe electrode potential, such as a potentiostat or galvanostat, and ademultiplexer to direct the potential to the desired reservoir. Ifdesired, the system would provide feedback, for example, to confirm thesuccessful delivery of a dose. This information could be transmittedback to the operator or to a computer monitoring system, eitheroptically by using a light-emitting diode (LED) or by other modes ofwireless transmission, such as RF. FIG. 2A illustrates one possibleconfiguration of the microchip device configuration, wherein microchipdevice 10 includes an array of reservoirs 12 containing drug to bereleased, power conversion, actuation electronics and local controllerarea 14, photocell 16, LED or wireless telemetry transmitter 18.

An ophthalmologist could initiate drug release and communication witheye-implanted microchips by directing an ophthalmic laser toward theappropriate portion of the microchip in the patient's eye. See FIG. 2B,which illustrates an eye 20 with optic nerve 21, wherein microchipdevice 28 is implanted at the back of the interior of the eye. Anophthalmic laser 30 directs power and data via laser light 32 throughcornea 22, lens 24, and vitreous humor 26, to power and communicate withthe implanted microchip device 28. Many ophthalmologists are alreadyskilled in the use of such lasers, so these procedures could be readilyperformed.

EXAMPLE 4

Orally Administered Microchips for Drug Delivery Having ProximityActuation

A potential advantage of orally administered, drug delivery microchipsor sensors is that they can be activated at a specific time or at aspecific location in the gastrointestinal tract. Such control over thetime and location of release can be achieved using pre-programmedmicroprocessors, remote control systems (e.g. wireless systems), orbiosensors. One method of initiating drug release or exposure of asensor at a particular location in the gastrointestinal tract wouldinvolve using a remote, wireless system of control that was highlylocation dependent. For example, a patient that just swallowed an orallyadministered microchip could wear a small RF transmitter on their belt.The filed produced by the RF transmitter would be designed to localizethe power at a specific location in the gastrointestinal tract. Multiplecoils or antennas could be used to more precisely locate the field sothat its signal could only be detected at the desired location. Themicrochip would travel through the gastrointestinal (GI) tract until itreached a position where it could detect the signal from thetransmitter.

As in Example 1, the microchip would receive power from the RFtransmitter and could release drug or expose internal sensors. Theposition of release or exposure in the gastrointestinal tract would becontrolled by the nature of the signal coming from the RF transmitter(i.e. strength of signal), the positioning of the transmitter (forexample, its position on the patient's belt), and the distance betweenthe microchip and the transmitter (which is based on how far themicrochip has traveled in the gastrointestinal tract).

This process is illustrated in FIG. 3, which shows a microchip device50A at a first location (i.e. the stomach) in the GI tract, themicrochip device 50B at a second location (i.e. the colon), and RFtransmitter 54 having an RF signal range shown by dashed line 56. As thedevice passes through the GI tract, it moves from position 50A, which isoutside the RF signal range 56, to position 50B, which is inside RFsignal range 56 and can be powered by the signal from RF transmitter 54.

EXAMPLE 5

Microchips Designed to Minimize Medical Errors

The inclusion of a microprocessor, memory, and a timer also can helpdecrease the potential for drug overdoses or the administration of thewrong drugs to patients. Safety protocols can be stored in the memoryand continuously checked by the microprocessor to prohibit (i) therelease of too much drug to a patient over a particular time interval,and/or (ii) the simultaneous release of two or more incompatible drugs.In addition, the microchip can store in memory the exact amount of drugdelivered, its time of delivery, and the amount of drug remaining in themicrochip. This information can be transmitted using wireless technology(for implants) or using standard computer connections (for external,in-line, or intravenous systems) to the physician or to a centralmonitoring system on a real-time basis. This allows the physician toremotely monitor the patient's condition.

Modifications and variations of the methods and devices described hereinwill be obvious to those skilled in the art from the foregoing detaileddescription. Such modifications and variations are intended to comewithin the scope of the appended claims.

1. A system for the controlled release or exposure of reservoir contentscomprising: a microchip device comprising a substrate, a plurality ofreservoirs in said substrate, reservoir contents in said reservoirs, andmeans for selectively controlling exposure of said reservoir contents,wherein the reservoir contents comprises a sensor which measuresintrinsic electrical signals or loads on tissue structures in vivo; anda telemetry system for the wireless transfer of data between themicrochip device and a remote controller, wherein the telemetry systemis adapted to transmit data from the sensor to the remote controller. 2.The system of claim 1, wherein the means comprises actuation electronicsto selectively open the reservoirs.
 3. The system of claim 2, whereinthe actuation electronics comprises components selected from the groupconsisting of multiplexers, demultiplexers, signal generators, signaloscillators, amplifiers, switches, potentiostats, and combinationsthereof.
 4. The system of claim 3, further comprising a local controllerfor controlling the actuation electronics.
 5. The system of claim 4,wherein the local controller comprises components selected from thegroup consisting of microprocessors, read only memory, random accessmemory, clocks, analog input/output devices, digital input/outputdevices, programmable logic circuits, and combinations thereof.
 6. Thesystem of claim 5, wherein the local controller can wirelesslycommunicate with the remote controller of the telemetry system.
 7. Thesystem of claim 6, wherein the data transfer is accomplished using afirst coil in the microchip device to inductively couple electromagneticenergy to a corresponding coil in the remote controller.
 8. The systemof claim 1, wherein the microchip device comprises a receiver whichcomprises a component selected from the group consisting of photocells,photodiodes, phototransistors, and ultrasonic receivers.
 9. The systemof claim 1, wherein the remote controller comprises a light-emittingdiode, a laser, or an ultrasonic transmitter.
 10. The system of claim 1,wherein each reservoir has a reservoir cap positioned on the reservoirover the reservoir contents, and wherein exposure of the reservoircontents is controlled by disintegration of the reservoir cap.
 11. Thesystem of claim 10, wherein the microchip device further comprises acathode, wherein at least one reservoir cap is an anode, and an electricpotential is applied between the cathode and anode to oxidize thereservoir cap and expose the reservoir contents to a surrounding fluid.12. The system of claim 1, wherein the microchip device is adapted forimplantation onto or in the eye of a human or animal, and wherein theremote controller comprises an ophthalmic laser.
 13. The system of claim1, wherein the microchip device is adapted for administration in vivo,and wherein the remote controller comprises a radio frequencytransmitter.
 14. The system of claim 1, further comprising arechargeable or on-demand power source which comprises a local componentwhich can wirelessly receive power from a remote transmitter.
 15. Asystem for the controlled exposure of a biosensor comprising: animplantable medical device comprising a substrate, a plurality ofreservoirs containing biosensors for exposure, reservoir caps positionedon the reservoir over the biosensors which measures intrinsic electricalsignals or loads on tissue structures in vivo, an electric power sourceand actuation electronics to control and direct the power todisintegrate the reservoir caps and expose the biosensor; and atelemetry system for the wireless transfer of data between theimplantable medical device and a remote controller, wherein thetelemetry system is adapted to transmit data from the biosensors to theremote controller.
 16. The system of claim 15, wherein the reservoir capconsists essentially of a metal film.
 17. The system of claim 15,wherein the substrate comprises silicon and the reservoir cap comprisesa metal film.
 18. The system of claim 1, wherein the intrinsicelectrical signal is an electrocardiogram or electroencephalogram. 19.The system of claim 1, wherein the intrinsic electrical signal is anelectrocardiogram or electroencephalogram.
 20. An implantable medicaldevice for sensing comprising: a substrate; at least two discretereservoirs in said substrate; a biosensor located inside each of said atleast two discrete reservoirs; at least two discrete reservoir capssealing the biosensors inside the reservoirs; an electric power sourceand actuation electronics for controlling and directing power to thereservoir caps to disintegrate the reservoir caps and expose thebiosensors; and wireless means or hardwires for the transfer ofbiosensor data between the implantable medical device and a pacemaker ordefibrillator.
 21. The medical device of claim 20, wherein the biosensorcan transduce the chemical potential of an analyte of interest into anelectrical signal.
 22. The medical device of claim 20, wherein thesubstrate comprises silicon and the reservoir caps comprise a metalfilm.